Laura R. Osborn
About Me
I am a Ph.D. candidate at the University of Arkansas for Medical Sciences, in the Graduate Program for Interdisciplinary Biomedical Sciences, Department of Pharmacology, Toxicology, and Experimental Therapeutics.
I conduct my dissertation research at the Arkansas Children's Research Institute.
I study the effects of repeated paclitaxel cycles on paclitaxel-induced peripheral neuropathy development and resolution and the role of epigenetics in regulating the peripheral nervous system response to paclitaxel.
I am interested in toxicology and the role epigenetics play in modulating adverse drug effects.
Strengths
Comfortable working with rodents and bacterial and mammalian cell cultures
Proficient in basic laboratory procedures including qPCR, ELISA, DNA and RNA extractions, and live cell imaging
Able to competently work with gas chromatography, high performance liquid chromatography, fluorescence detection, and mass spectrometry
Able to comfortably deliver oral presentations
Proficient in Microsoft Office, GraphPad Prism, and Ingenuity Pathways Analysis
Experienced in customer service
Publications and Presentations
Barnette DA, Schleiff M A, Osborn LR, Flynn N, Matlock M, Swamidass SJ, and Miller GP. “Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.” Toxicology 440.152478 (2020).
Muller JE, Osborn LR, Traver JR, Hillesheim PC, Zeller M, and Mirjafari A. “2-(Octadecylsulfanyl)-1,3-thiazole.” IUCrData 5.2 (2020).
Crosby SV, Ahmed IY, Osborn LR, Wang Z, Schleiff MA, Fantegrossi WE, Nagar S, Prather PL, Boysen G, and Miller GP. “Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes.” Metabolites, 12(8), 773, (2022).
Osborn LR, Bishop MG, Rodriguez KA, and Stephens KE. "The effects of repeated paclitaxel exposure on paclitaxel-induced peripheral neuropathy development." Society of Toxicology South Central Regional Chapter Fall Meeting. Oral Presentation. New Orleans, LA. 2023.
Osborn LR, Bishop MG, Rodriguez KA, and Stephens KE. "Effects of repeated paclitaxel exposure on paclitaxel-induced peripheral neuropathy development." Arkansas Biosciences Institute research symposium. Poster Presentation. Little Rock, AR. 2023.
Osborn LR, Bishop MG, Rodriguez KA, and Stephens KE. "Mouse model of paclitaxel-induced peripheral neuropathy." Winthrop P. Rockefeller Cancer Institute research symposium. Poster Presentation. Little Rock, AR. 2023.